How it works
Glutathione (GSH) neutralizes reactive oxygen species, supports phase II liver detoxification, and inhibits tyrosinase (the enzyme that drives melanin synthesis). Levels fall with age, illness, and oxidative stress.
The evidence
Strong biochemical role; intravenous and injectable use is supported by small clinical studies in skin lightening, oxidative-stress conditions, and adjunct use in fatty liver. Oral bioavailability is poor — liposomal or injectable forms preferred.
Typical dosing
Injection: 600–1200 mg IM or subcutaneous, 1–2× weekly. Cycles typically 8–12 weeks.
Side effects
Common
- Injection-site discomfort
Less common
- Headache, dizziness
Drug interactions
- Generally minimal