Dermatology, compounded for you.

Tretinoin, spironolactone, minoxidil — prescription-strength formulas matched to your skin, not a shelf.

See if I qualify 4.5
  • Compounded to your skin
  • From $45/mo
  • FSA/HSA eligible
  • Doctor-reviewed in 24 hrs

From $45/moClinician review in 24hFree 2-day shipping

Right for you if
Mild-to-moderate acne, melasma, or texture concerns Want prescription-strength formulas matched to skin type Willing to commit to daily SPF and 8–12 week consistency

Care in this category

Tretinoin

Tretinoin

Tretinoin · Azelaic · Niacinamide

From $59/mo
Hormonal acne
Spironolactone (topical)

Spironolactone (topical)

Spiro · Clindamycin · Azelaic

From $49/mo
Minoxidil + Spironolactone

Minoxidil + Spironolactone

Topical minoxidil · Spironolactone

From $45/mo
Hydroquinone

Hydroquinone

Hydroquinone · Tretinoin · Vit C

From $59/mo

Prescription treatments require an online visit reviewed by a U.S.-licensed provider, who determines if a treatment is clinically appropriate. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.

★★★★★
Absolutely love Zappy Health. Very professional, customer service is amazing. Fast shipping and everything is certified. Zappy Health has transformed my life. I am in the best shape with my health! Thank you Zappy Health for helping me achieve my goals on a wellness journey.
Nebiat Verified Trustpilot review
★★★★★
Zappy Health is extremely easy to enroll in. They were helpful every step of the way & I knew within the hour of submitting my application that I was a candidate. As soon as I made my decision to start my journey the communication from them has been impressive.
Jayne Verified Trustpilot review
★★★★★
The initial process of ordering the medication was extremely easy. The app is very helpful and I cannot wait to receive my medication and start my journey. Thank you so much!!
Amy Verified Trustpilot review

Verified Trustpilot reviews, published as written. Individual results vary and are not typical.

The shelf is full of half-empty bottles, and the mirror still hasn't changed its mind.

How it works

How skin care works

1

Two-minute quiz

Tell us your skin type, concerns, and history — and add photos where they help.

2

Clinician reviews

A U.S.-licensed clinician reviews and compounds the right actives and concentration for your skin.

3

Your formula ships free

A single compounded formula arrives — no juggling five products, no guessing at strengths.

4

Adjust over 8–12 weeks

Texture improves first; pigment and acne resolve with consistency. Your clinician tunes strength as tolerance builds.

Why this works

Since 1971

Tretinoin, FDA-approved for acne and photoaging — the most-studied topical retinoid.

One formula

Tretinoin, niacinamide, and azelaic acid in one routine, not five bottles.

4–12 weeks

Texture improves in 4–6 weeks; pigment and acne resolve over 8–12 weeks.

Matched strength

Set to your skin type — the line between results and irritation.

Two honest requirements: daily SPF 30+ is non-negotiable on prescription topicals, and results need 8–12 weeks of consistency. We compound to reduce irritation — but no formula skips the sunscreen or the patience.

A note from our medical director
Most people who come to us for skin or hair have been layering five products that quietly fight each other — a scrub, a serum, a spot treatment, whatever the last video told them to buy. We'd rather take that whole shelf away and give you one formula built for your skin, at a strength you can actually live with day to day. What we watch for most is the person who goes too hard too fast and quits the week their face gets red and flaky. The real work here is patience and sunscreen, not intensity, so we'd rather start you gentle and earn your trust than scare you off in month one.
Medical Director · Zappy clinical team

See how it works

Two minutes on what to expect — from the quiz to your first shipment.

Short explainer — video coming soon.

before & after

Before
After · 12 weeks
Illustrative example. Individual results vary and are not guaranteed; images are not necessarily typical.

Questions, answered.

What strength of tretinoin do I get?
Your clinician compounds the right concentration for your skin type, usually 0.025% to 0.1% — enough for results without excess irritation.
Will spironolactone help my acne?
Hormonal acne responds well to spironolactone for most members within 8–12 weeks. We offer it topically to reduce systemic side effects.
How fast will my skin change?
Texture improves in 4–6 weeks; pigment and acne typically resolve over 8–12 weeks of consistent use.
Can I use this with my retinol?
Your clinician compounds a single formula that replaces over-the-counter retinol — layering both just adds irritation.
What about sun exposure?
Daily SPF 30+ is non-negotiable on prescription topicals — the single biggest factor in your results. Guidance is in your plan.
Do you treat hair loss too?
Yes. Topical minoxidil with spironolactone is our prescription-strength combo for women's pattern hair loss — the kind most clinics gate behind a dermatology visit.
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