Peptides & longevity

NAD+ Injection vs Spray

Injection bypasses gut absorption. Nasal spray is easier. The question is which one your body actually uses.

NAD+ Injection
NAD+ Injection
Subcutaneous or IM
Coenzyme
vs
N
NAD+ Spray
Intranasal
Coenzyme

NAD+ is the same coenzyme regardless of how it enters your body. The choice between injection and nasal spray is mostly about bioavailability, convenience, and how much active NAD+ ends up in tissue. Oral NAD+ is poorly absorbed, which is why neither of these routes goes through the gut.

Side by side.

 
NAD+ Injection
NAD+ Spray
Route
Subcutaneous or intramuscular
Intranasal mucosal absorption
Bioavailability
Highest — bypasses GI tract
Moderate — variable nasal absorption
Convenience
Requires injection skill
Pump and inhale; no needles
Onset of effect
Minutes to hours
Minutes
Typical dose
100–500 mg per session
50–100 mg per session
Side effects
Flushing common during slow push
Mild nasal irritation; less flushing

Who picks which.

NAD+ Injection
  • Want the highest tissue NAD+ levels
  • Already comfortable with subcutaneous injections from GLP-1 or peptides
View NAD+ Injection
NAD+ Spray
  • Needle-averse
  • Want a daily, low-dose maintenance option vs. weekly higher-dose sessions
Our verdict

Injection delivers more NAD+ per session and is the standard for clinical protocols. Spray wins on convenience and is reasonable for daily maintenance. Many members use injection for a loading phase and switch to spray for maintenance.

See if I qualify

Prescription treatments require an online visit reviewed by a U.S.-licensed provider, who determines if a treatment is clinically appropriate. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.

Questions, answered.

How often should I dose?
Injection: 1–3× weekly during a loading phase, then weekly maintenance. Spray: daily, often split across two doses.
Is oral NAD+ a real alternative?
Oral NAD+ is poorly absorbed. Oral precursors (NR, NMN) are the only meaningfully bioavailable oral route.