NAD+
Nicotinamide adenine dinucleotide — the coenzyme behind cellular energy production. Injection or nasal spray, with clinician oversight.
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Prescriptions require an online visit reviewed by a U.S.-licensed provider. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.
Who it’s for
- Recovering from injury, surgery, or chronic joint wear
- Want a clinician-supervised peptide course, not gray-market vials
- Comfortable with subcutaneous injections (most courses)
It's the kind of tired a full night's sleep stopped touching.
how it works
An essential coenzyme in cellular energy production and DNA repair — supplemented via injection, nasal spray, or oral precursors.
What we can and can't tell you
Direct injectable NAD+ is an active research area, not a settled outcome. The measurable human evidence to date is on oral precursors raising tissue NAD+ levels; downstream energy and longevity benefits are biologically plausible but not proven at trial scale. Clinician oversight, not marketing claims.
- Who makes it A LegitScript-verified 503A compounding pharmacy, from your prescription — never a gray-market or overseas supplier
- To what standard USP <797> sterile compounding and USP <800> hazardous-drug handling, where applicable
Compounded medications are not FDA-approved, are not reviewed by the FDA for safety or effectiveness, and are not generic equivalents of any brand-name drug.
what the first months look like
Dose is introduced slowly. Infusion or injection is deliberately paced — flushing and headache track how fast NAD+ goes in, not whether it's working.
Any change in how you feel is anecdotal at this stage and varies widely person to person. Set expectations, not a stopwatch — the downstream benefits are not proven at trial scale.
Cadence settles into a routine (weekly injection or intermittent spray). This is a maintenance protocol, not a course with a fixed endpoint.
Clinician reviews tolerance and dose. Pacing down for flushing or nausea is routine, not failure.
Dosing, step by step
| Injection | 100–500 mg subcutaneous — 1–3× weekly under clinician supervision |
|---|---|
| Nasal spray | 50–100 mg daily — used intermittently |
Ranges restate the ingredient profile. Your clinician sets the actual dose and cadence and adjusts for tolerance — flushing and nausea are dose-dependent, so slower is often better.
And when it gets rough
- Flushing Dose-dependent and paced — slowing the injection or infusion rate is the main lever. Tell your clinician if it's intense.
- Headache Hydrate around dosing; it tracks how fast the dose goes in and eases as the pace is adjusted.
- Nausea (dose-dependent) Slower administration and a lower dose usually settle it — coordinate the adjustment with your clinician.
- Injection-site reactions Rotate sites; mild local redness is common and short-lived. Spreading or persistent reactions are a clinician call.
We're honest with people about where this one sits: the strongest human evidence is still on the oral precursors, and direct NAD+ is newer ground we're watching closely. So we start low and go slow — most of the flushing and nausea people worry about comes from pushing the dose too fast, not from the compound itself. We reach for it when someone's energy and recovery aren't tracking with their sleep and their labs, as one piece of a plan rather than the whole plan. If you're on metformin or anything that touches how you run your metabolism, tell us before we start.
Three steps, no insurance hoops
Take the quiz
Two minutes. Tell us your symptoms, history, and goals.
Clinician reviews
A U.S.-licensed clinician reviews and writes your plan within 24 hours.
Care ships free
Your medication arrives in days. Refills auto. Check-ins included.
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What members say
4.5Absolutely love Zappy Health. Very professional, customer service is amazing. Fast shipping and everything is certified. Zappy Health has transformed my life. I am in the best shape with my health! Thank you Zappy Health for helping me achieve my goals on a wellness journey.
Zappy Health is extremely easy to enroll in. They were helpful every step of the way & I knew within the hour of submitting my application that I was a candidate. As soon as I made my decision to start my journey the communication from them has been impressive.
The initial process of ordering the medication was extremely easy. The app is very helpful and I cannot wait to receive my medication and start my journey. Thank you so much!!
Verified Trustpilot reviews, published as written. Individual results vary and are not typical.
Questions, answered.
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