Wegovy vs Zepbound
Two FDA-approved brands, two different molecules. The choice is really semaglutide vs tirzepatide, with branded pricing.
Wegovy (Novo Nordisk) and Zepbound (Eli Lilly) are the FDA-approved branded weight-loss medications. Wegovy contains semaglutide; Zepbound contains tirzepatide. If you're choosing between the brands, you're really choosing between the two molecules — at branded pricing.
Side by side.
Who picks which.
- You want the FDA-approved branded medication and have insurance coverage
- Established cardiovascular disease — unique SELECT outcome data
- Comfortable on semaglutide already
- You want the FDA-approved branded medication with the strongest weight-loss data
- Insurance covers Zepbound but not Wegovy
- Insulin-resistant or pre-diabetic profile
Both are FDA-approved and effective. Wegovy has the cardiovascular outcome data; Zepbound has the higher weight-loss numbers. If neither is covered by your insurance, compounded versions of the underlying molecules are a lower-cash-cost option prescribed under physician oversight — though they are not FDA-approved. Your clinician can advise whether one fits.
See if I qualifyPrescription treatments require an online visit reviewed by a U.S.-licensed provider, who determines if a treatment is clinically appropriate. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.
Questions, answered.
What do these cost without insurance?
How does the compounded version differ from the brand?
Related comparisons
All comparesSame family, different math: GLP-1 alone or GLP-1 + GIP. Here is how to choose.
Read the comparison →One is FDA-approved; the other is compounded by a 503A pharmacy. Here is what changes between them — and what to weigh.
Read the comparison →Different molecules, different makers. Zepbound is tirzepatide; Ozempic is semaglutide.
Read the comparison →