Zepbound®
Eli Lilly's FDA-approved tirzepatide for chronic weight management, in the original manufacturer pen.
- −20.9%Mean body weight at week 72 on 15 mg
- FDAApproved for chronic weight management
SURMOUNT-1 · NEJM 2022 · n=2,539
See the price at every dose
| 2.5 mg | starting dose | $299/mo |
|---|---|---|
| 5 mg | $399/mo | |
| 7.5–15 mg | maintenance range | $449/mo |
Lilly's pricing requires you to refill within 45 days of your previous delivery.
We send your prescription to LillyDirect and Eli Lilly bills you directly — Zappy never charges you for the medication, and we don't mark it up.
- Doctor-reviewed in 24 hours
- Free 2-day shipping
- Pause or cancel anytime
Prescriptions require an online visit reviewed by a U.S.-licensed provider. Individual results vary.
Who it’s for
- BMI 27+ or 30+ depending on comorbidities
- Tried diet + exercise without lasting results
- Want food noise quieted, not brute appetite suppression
Some days you don't want a version of it — you want the pen the box was made for.
What the trials actually found
Mean body weight at week 72 on 15 mg — Zepbound is the SURMOUNT-1 drug
SURMOUNT-1 · NEJM 2022 · n=2,539 ↗Approved for chronic weight management — branded tirzepatide
FDA labelThese results are Zepbound's, in the branded FDA-approved pen. Trial data belongs to the product it was generated on and does not transfer to other preparations.
what the first months look like
Priming dose (2.5 mg).
2.5 mg steps ~monthly toward maintenance.
Maintenance at 10–15 mg — where the week-72 trial numbers live.
Dosing, step by step
| Ladder | 2.5 mg start, +2.5 mg ~monthly to 10–15 mg — label-standard |
|---|
And when it gets rough
- Nausea Mechanical, dose-tracked, fades with adaptation — pace the steps with your clinician.
- Injection-site reactions Rotate sites; mild and local is normal, spreading redness is a call.
Safety information
Every prescription is reviewed by a U.S.-licensed clinician who decides whether this medication is appropriate for you. Tell them during your visit if any of the following applies to you or your family.
In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Full GLP-1 safety information →When someone tells us they want the branded pen, we don't try to talk them out of it. Knowing exactly what you're injecting — same manufacturer, same box the pharmacy hands everyone else — is worth something, and for a lot of people that certainty is what makes them actually stay on treatment instead of second-guessing every dose. Tirzepatide works on two appetite pathways rather than one, which tends to make the climb to a full dose more manageable, but the first few weeks still ask something of you: the nausea and the slowed digestion are real, and we'd rather titrate up slowly and keep you comfortable than chase a number on the scale. What we watch most isn't the weight — it's whether you're getting enough protein and not quietly white-knuckling through side effects you were never meant to tough out.
Three steps, no insurance hoops
Take the quiz
Two minutes. Tell us your symptoms, history, and goals.
Clinician reviews
A U.S.-licensed clinician reviews and writes your plan within 24 hours.
Care ships free
Your medication arrives in days. Refills auto. Check-ins included.
Comparing options?
see it in real life
What members say
4.5I love Zappy Health!! They started me on my GLP-1 journey in February of 2024! They helped me when my own doctors wouldn't! I have exceeded my goal weight and have a healthy BMI of 22! I started at 49! Thank you Zappy for all your kindness, and your support. I will be forever grateful.
I do my online survey every month to let them know about my weight loss and I've received my injections every month. Flat rate, no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way.
I had read many reviews and decided to give Zappy my business. I lost the needed weight and feel so much the better for it. I received all of my medication on time. I do feel this company has a high regard for each client they treat. They deserve the 5-star rating and I highly recommend them.
Verified Trustpilot reviews, published as written. Individual results vary and are not typical.
Questions, answered.
Do I need insurance to start?
How fast will I see results?
What if I have side effects?
Read before you start
From the Zappy clinical team, in plain language.
Care that shows up — and stays.
Ready when you are.
A licensed clinician reviews your visit within 24 hours.
Start my visit · Medication $299–$449/mo