Semaglutide
A weekly GLP-1 that quiets food noise and steadies blood sugar — compounded for you by a licensed U.S. pharmacy and titrated by a clinician.
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Prescriptions require an online visit reviewed by a U.S.-licensed provider. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.
Who it’s for
- BMI 27+ or 30+ depending on comorbidities
- Tried diet + exercise without lasting results
- Want food noise quieted, not brute appetite suppression
Most people notice the quiet before they notice the scale.
how it works
A once-weekly GLP-1 receptor agonist that slows gastric emptying, improves insulin sensitivity, and quiets the appetite signaling centers in the brain.
What we can and can't tell you
Response varies from person to person, and the loss holds only while treatment continues — most people regain weight after stopping without a plan to hold it.
- Who makes it A LegitScript-verified 503A compounding pharmacy, from your prescription — never a gray-market or overseas supplier
- To what standard USP <797> sterile compounding and USP <800> hazardous-drug handling, where applicable
Compounded medications are not FDA-approved, are not reviewed by the FDA for safety or effectiveness, and are not generic equivalents of any brand-name drug.
what the first months look like
Starter dose (0.25 mg). Appetite quiets first; the scale stays put — that's expected.
Dose steps up ~every 4 weeks. Side effects cluster after each step, then fade as your gut adapts.
Maintenance dose. This is where the meaningful change builds — over months, not the first few weeks.
Check-ins, dose tweaks, and a real plan before any stop — regain after stopping is physiology, not failure.
Dosing, step by step
| Start | 0.25 mg weekly — tolerability dose — trains the gut, not the scale |
|---|---|
| Step 2 | 0.5 mg weekly — ~week 5 |
| Step 3 | 1.0 mg weekly — ~week 9 |
| Step 4 | 1.7 mg weekly — ~week 13 |
| Target | 2.4 mg weekly — most members maintain between 1.0–2.4 mg |
Label-standard ladder. Your clinician sets the pace — holding a step longer for side effects is routine, not failure.
And when it gets rough
- Nausea Smaller, slower, lower-fat meals — tracks dose steps, then fades. Persistent vomiting is a same-day clinician call.
- Constipation Fluids, then fiber, then magnesium — escalate with your clinician.
- Fatigue (early) Usually intake: hydration, electrolytes, and your protein floor.
- Reflux Earlier, smaller dinners; raise the head of the bed; flag new or worsening to your clinician.
Safety information
Every prescription is reviewed by a U.S.-licensed clinician who decides whether this medication is appropriate for you. Tell them during your visit if any of the following applies to you or your family.
In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Full GLP-1 safety information →Semaglutide is where we start most people. Of the options we compound, it has the longest real-world track record and the most forgiving dosing — and for most people, it does the job. We only reach for something else if your body tells us to.
Three steps, no insurance hoops
Take the quiz
Two minutes. Tell us your symptoms, history, and goals.
Clinician reviews
A U.S.-licensed clinician reviews and writes your plan within 24 hours.
Care ships free
Your medication arrives in days. Refills auto. Check-ins included.
Comparing options?
see it in real life
What members say
4.5I love Zappy Health!! They started me on my GLP-1 journey in February of 2024! They helped me when my own doctors wouldn't! I have exceeded my goal weight and have a healthy BMI of 22! I started at 49! Thank you Zappy for all your kindness, and your support. I will be forever grateful.
I do my online survey every month to let them know about my weight loss and I've received my injections every month. Flat rate, no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way.
I had read many reviews and decided to give Zappy my business. I lost the needed weight and feel so much the better for it. I received all of my medication on time. I do feel this company has a high regard for each client they treat. They deserve the 5-star rating and I highly recommend them.
Verified Trustpilot reviews, published as written. Individual results vary and are not typical.
Questions, answered.
What is compounded semaglutide?
How is it dosed?
Do I need insurance to start?
How fast will I see results?
What if I have side effects?
Read before you start
From the Zappy clinical team, in plain language.
Care that shows up — and stays.
Ready when you are.
A licensed clinician reviews your visit within 24 hours.
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