Tirzepatide
A dual GLP-1 + GIP agonist — a slower ramp and a gentler stomach at higher doses, compounded for you by a licensed U.S. pharmacy and titrated by a clinician.
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Prescriptions require an online visit reviewed by a U.S.-licensed provider. Compounded medications are prepared by licensed U.S. pharmacies and are not FDA-approved. Individual results vary.
Who it’s for
- BMI 27+ or 30+ depending on comorbidities
- Tried diet + exercise without lasting results
- Want food noise quieted, not brute appetite suppression
The dual-hormone one — a slower climb, and for many, a gentler stomach.
how it works
A once-weekly dual agonist of GLP-1 and GIP receptors — the GIP arm appears to drive additional weight loss and improve high-dose tolerability.
What we can and can't tell you
There is no completed cardiovascular outcomes study for this molecule yet. If long-term heart protection is what you're weighing, that gap is real — semaglutide is further along on it.
- Who makes it A LegitScript-verified 503A compounding pharmacy, from your prescription — never a gray-market or overseas supplier
- To what standard USP <797> sterile compounding and USP <800> hazardous-drug handling, where applicable
Compounded medications are not FDA-approved, are not reviewed by the FDA for safety or effectiveness, and are not generic equivalents of any brand-name drug.
what the first months look like
Priming dose (2.5 mg). Not a treatment dose — it is there to settle your stomach into the medication.
Titration in 2.5 mg steps ~every 4 weeks. Side effects cluster after each step; pacing is the main lever.
Maintenance at 10–15 mg. This is where the change builds — over months, not weeks.
Check-ins and dose adjustment; because weight tends to return after stopping, the exit is a planned, tapered event.
Dosing, step by step
| Start | 2.5 mg weekly — priming dose, 4 weeks |
|---|---|
| Steps | +2.5 mg ~every 4 weeks — 5 → 7.5 → 10 → 12.5 mg as tolerated |
| Target | 10–15 mg weekly — the 10→15 step buys the least extra loss — weigh it against side effects |
Label-standard ladder; slower-than-label pacing is common and clinically fine.
And when it gets rough
- Nausea Same mechanism as all GLP-1s — smaller low-fat meals, slower steps. Report anything that spikes instead of fading.
- Constipation Fluids, fiber, magnesium — in that order, with your clinician.
- Early fullness Work with it: protein first on the plate, stop at the first fullness signal.
- Injection-site redness Rotate sites weekly; mild local reactions are common and short-lived.
Safety information
Every prescription is reviewed by a U.S.-licensed clinician who decides whether this medication is appropriate for you. Tell them during your visit if any of the following applies to you or your family.
In rodent studies, semaglutide and tirzepatide caused thyroid C-cell tumors. It is not known whether they cause these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use this medication if you or any of your family have had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Full GLP-1 safety information →We reach for tirzepatide when someone wants the strongest option we compound, or when they've stalled on semaglutide. It works on two appetite pathways instead of one, and the trade-off is a longer, slower titration — which most people tolerate better than they expect. We watch the same things we always watch: that you're getting enough protein and not white-knuckling side effects you were never meant to tough out.
Three steps, no insurance hoops
Take the quiz
Two minutes. Tell us your symptoms, history, and goals.
Clinician reviews
A U.S.-licensed clinician reviews and writes your plan within 24 hours.
Care ships free
Your medication arrives in days. Refills auto. Check-ins included.
Comparing options?
see it in real life
What members say
4.5I love Zappy Health!! They started me on my GLP-1 journey in February of 2024! They helped me when my own doctors wouldn't! I have exceeded my goal weight and have a healthy BMI of 22! I started at 49! Thank you Zappy for all your kindness, and your support. I will be forever grateful.
I do my online survey every month to let them know about my weight loss and I've received my injections every month. Flat rate, no hidden fees, and the cost doesn't increase. This company is great and helps you every step of the way.
I had read many reviews and decided to give Zappy my business. I lost the needed weight and feel so much the better for it. I received all of my medication on time. I do feel this company has a high regard for each client they treat. They deserve the 5-star rating and I highly recommend them.
Verified Trustpilot reviews, published as written. Individual results vary and are not typical.
Questions, answered.
Why dual GLP-1 + GIP?
Do I need insurance to start?
How fast will I see results?
What if I have side effects?
Read before you start
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